La glucosamine is one cup sugar useful for the synthesis of natural substances such as sugars, fats and protein. It exists in 3 main forms: glucosamine sulfate, glucosamine hydrochloride and glucosamine acetyl phosphate.
La glucosamine acetyl phosphate is a derivative of glucosamine which is found inheparin, in the polysaccharides present in bacterial walls, chitin and glycoproteins.
It is synthesized by the body and together with glucuronic acid creates thehyaluronic acid.
Glucosamine is also found in some non-human animal tissues, including mollusc shells, animal bones, and fungi. Supplemental forms of glucosamine are often produced from these natural sources.
Index
What is it for?
Glucosamine contributes to keep cartilage solid of the joints, protecting the joint ends from friction.
Glucosamine acetyl-phosphate is an adjuvant in therapies against joint degeneration caused by arthrosis, in the treatment of chronic inflammatory bowel diseases (ulcerative colitis and Crohn's disease), against multiple sclerosis and other autoimmune diseases.
Glucosamine can be taken orally in tablets or applied topically in the form of a cream or ointment.
dosage
The typical glucosamine dosage is 1500 mg per day, to be taken in one or more doses during the day. Scientific data shows that its effectiveness is extended when combined with the use of chondroitin.
As regards specifically glucosamine acetyl-phosphate, the Ministry of Health classifies it as a "Substance without a defined daily intake"; the general indication about the intake of supplements of this specific substance is "synthesis of hyaluronic acid" (120-240 mg per day).
Controindicazioni
To date, there are insufficient scientific studies to establish the safety of glucosamine acetyl-phosphate intake; in case of pregnancy or breastfeeding is prudent avoid this substance.
In addition, glucosamine can worsen blood sugar control in people with diabetes by affecting blood sugar levels.
Effetti collaterali
Glucosamine derivatives supplements tend to be safe, but there are some risks.
Possible non-serious adverse reactions include:
- nausea and vomit
- Diarrhea
- constipation
- stomach ache
- abdominal pain
It is good to refrain from using this supplement in case of ascertained hypersensitivity to the active ingredient; severe allergic reactions are very rare but include:
- skin rash
- pruritus
- swelling (especially of the face, tongue and throat)
- breathing difficulties
- dizziness and fainting
Conclusions
Glucosamine exists naturally in the human body and plays a vital role in development and in maintenance of the joints.
Although glucosamine is used to treat joint diseases, inflammatory diseases, multiple sclerosis and Crohn's disease, most research only supports its efficacy for long-term management of osteoarthritis symptoms.
Taking glucosamine supplements is safe for most people in doses of no more than 1500 mg per day, but it can cause small side effects.
If you are looking for relief from osteoarthritis, glucosamine supplementation may help, but make sure before speaking to your doctor.
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